Proposed Mechanism of Action
Pulmozyme addresses abnormal mucus associated with Cystic Fibrosis
Pulmozyme has been shown in vitro to cleave extracellular DNA in mucus, which is believed to reduce adhesiveness. (Ref: 1)
- Extracellular DNA is a major contributor to high adhesiveness and viscoelasticity (Ref: 2,3)
- The effect of cleaving extracellular DNA in CF mucus is to reduce mucus adhesiveness and viscoelasticity (Ref: 1,3-5)
Pulmozyme reduces viscoelasticity, which is believed to reduce mucus adhesiveness. (Ref: 1)
Next Steps
