Proposed Mechanism of Action
Pulmozyme addresses abnormal mucus associated with CF
Pulmozyme has been shown in vitro to cleave extracellular DNA in mucus, which is believed to reduce adhesiveness. (Ref: 1)
- Extracellular DNA is a major contributor to high adhesiveness and viscoelasticity (Ref: 2,3)
- The effect of cleaving extracellular DNA in CF mucus is to reduce mucus adhesiveness and viscoelasticity (Ref: 1,3-5)
Pulmozyme reduces viscoelasticity, which is believed to reduce mucus adhesiveness. (Ref: 1)
Next Steps
