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Pulmozyme® (dornase alfa) is indicated for daily administration along with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Important Safety Information

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or You may also report side effects to Genentech at 1-888-835-2555.

For further information, please see the Pulmozyme full Prescribing Information.

Pediatric Use

The safety and effectiveness of Pulmozyme have been established in patients 5 years of age and older. While clinical trial data are limited in patients younger than 5 years of age, the use of PULMOZYME should be considered for pediatric CF patients who may experience potential benefit in lung function or who may be at risk of respiratory tract infection.

The safety of Pulmozyme given by daily inhalation for 2 weeks has been studied using 98 CF patients with 65 of them aged 3 months to <5 years (younger group) and 33 aged 5 years to <10 years (older group). The PARI BABY™ reusable nebulizer (which uses a face mask instead of a mouthpiece) was used in patients who were unable to show that they could breathe in or out using their mouth throughout the entire treatment period. Overall, the kind of side effects observed in children was similar to those seen in larger trials in older patients.

Patient Financial Support

We are here to help you get the treatment you need.

Genentech has been committed to CF for over 17 years and can connect you with the medicine you need. We offer programs to help eligible patients get Pulmozyme, regardless of ability to pay.

Pulmozyme Access Solutions®. If you are worried about paying for Pulmozyme, we are here to help. Whether you have healthcare coverage or not, we offer help by:

  • Finding out if your healthcare plan pays for your medicine
  • Guiding you through the process of getting your medicine
  • Connecting you with our patient financial assistance programs

Learn more ›

Pulmozyme Co-Pay Card Program. If you are concerned about your co-pay, you may be eligible for our Pulmozyme Co-Pay Card Program. This program may help you with the out-of-pocket (OOP) costs of your Pulmozyme prescription.
Learn more ›

Genentech® Access to Care Foundation. If you do not have health insurance and/or cannot afford the cost of Pulmozyme, you may be eligible to receive your medicine free of charge. Learn more ›