Customer Contact Center:
1-888-PLMZYME (756-9963)


Pulmozyme® (dornase alfa) is indicated for daily administration along with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Important Safety Information

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or You may also report side effects to Genentech at 1-888-835-2555.

For further information, please see the Pulmozyme full Prescribing Information.

Pediatric Use

The safety and effectiveness of Pulmozyme have been established in patients 5 years of age and older. While clinical trial data are limited in patients younger than 5 years of age, the use of PULMOZYME should be considered for pediatric CF patients who may experience potential benefit in lung function or who may be at risk of respiratory tract infection.

The safety of Pulmozyme given by daily inhalation for 2 weeks has been studied using 98 CF patients with 65 of them aged 3 months to <5 years (younger group) and 33 aged 5 years to <10 years (older group). The PARI BABY™ reusable nebulizer (which uses a face mask instead of a mouthpiece) was used in patients who were unable to show that they could breathe in or out using their mouth throughout the entire treatment period. Overall, the kind of side effects observed in children was similar to those seen in larger trials in older patients.

Pulmozyme Access Solutions

Financial Support

Pulmozyme® Access Solutions® is here to help you access your medicines. We offer coverage and reimbursement support, patient assistance, and informational resources for both healthcare providers and their patients.

Pulmozyme Access Solutions Service Offerings
    • Help with benefits and coverage issues
      • Benefits investigation
      • Prior authorization
      • Recertification
    • Help with reimbursement issues
      • Denials and appeals
      • Billing and coding information
    • Genentech® Access to Care Foundation (GATCF) support for qualifying uninsured and rendered uninsured patients
    • Referrals to co-pay foundations for co-pay assistance
    • Pulmozyme Co-pay Card
    • CF Living
    • StarteRx Program
    • My Patient Solutions, our online patient management tool
    • Communication assistance services
      • Translation services
      • Telephone to telephone typewriter (TTY) services
    • Product spoilage and replacement information
    • Medicare/Medicaid search tool
    • Glossary of access and reimbursement terms

At Pulmozyme Access Solutions, we're here to help find a way for you to get the medicine your doctor has prescribed, even if you have no insurance. When you or your doctor's office call Pulmozyme Access Solutions, you will be connected with one of our experts, whose sole job is to make sure that you get the coverage or reimbursement help you need.

We work hard to make information you need about coverage and reimbursement easily available 24 hours a day. You can reach us: