Living with Cystic Fibrosis: Brian's Story

Lessons Brian Learned Living with Cystic Fibrosis (CF) Lessons Brian Learned Living with Cystic Fibrosis (CF)

Every CF patient has a story. Jordan, Brian, and Emily have shared theirs to inspire other patients.

Living with cystic fibrosis (CF) can be tough, but you're not alone! Many patients have overcome challenges and realized the importance of prioritizing their treatments.

Learn from their experience and see how their everyday lives have changed for the better.

My mindset prevented me from seeing the true impact of CF, or how important my treatments really are

How are lungs affected by CF different?

For people living with CF, the mucus in the lungs is thicker than normal, and becomes a source of inflammation and infection that can lead to lung damage. Learn more ›
Sticky mucus contributes to the progression of CF over time. CF can cause lung damage, even if there are no symptoms.
It gets hard to stay on top of your medications, especially if you don't understand the impact that CF can have

Why is Pulmozyme an important part of my cystic fibrosis treatment regimen?

Pulmozyme works uniquely to help thin and loosen mucus. Even when you can't feel Pulmozyme working to fight CF, it is. Learn more ›

Partner with your CF Care Team to come up with a treatment routine that works best for you.

Once you find a routine, your medications just become part of your life, and they don't become so much of a burden

Be sure to stick to your CF treatment routine to help manage the course of your disease.

How can I fit my Pulmozyme treatment into my daily routine?

Finding the time and place to take your treatments, like Pulmozyme, isn't always easy. But having a routine that fits your lifestyle may help you stay in control and assist in your fight against CF. Learn more ›

The effect of Pulmozyme on exercise tolerance has not been established in adults or children.

Please see the full Pulmozyme Prescribing Information and Safety Information.

Watch more CF Life Lessons

Indication and Important Safety Information

Indication and Usage

Pulmozyme (dornase alfa) is indicated for daily administration along with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Important Safety Information

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion, and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

Pediatric Use

The safety and effectiveness of Pulmozyme have been established in patients 5 years of age and older. While clinical trial data are limited in patients younger than 5 years of age, the use of Pulmozyme should be considered for pediatric CF patients who may experience potential benefit in lung function or who may be at risk of respiratory tract infection.

The safety of Pulmozyme given by daily inhalation for 2 weeks has been studied using 98 CF patients with 65 of them aged 3 months to <5 years (younger group) and 33 aged 5 years to <10 years (older group). The PARI BABY™ reusable nebulizer (which uses a face mask instead of a mouthpiece) was used in patients who were unable to show that they could breathe in or out using their mouth throughout the entire treatment period. Overall, the kind of side effects observed in children was similar to those seen in larger trials in older patients.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or You may also report side effects to Genentech at 1-888-835-2555.

For further information, please see the full Pulmozyme Prescribing Information. If you have questions, please discuss them with your CF Care Team.