Cystic Fibrosis and Pulmozyme® (dornase alfa) Videos and Downloads

Your one-stop shop for everything you need to know about Pulmozyme

Pulmozyme video library

The following videos will help you learn about Pulmozyme and how to manage your CF treatments, as well as tips on diet and exercise, and much more.

Lessons Learned Living with CF

Jordan chooses to make Pulmozyme a priority

CF Life Lessons: I did not always understand the importance of sustaining my daily CF care

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CF Life Lessons: Once my perspective changed, I decided to do my treatments and make that a priority

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CF Life Lessons: When I was in college, doing Pulmozyme and my other treatments was not a high priority for me

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Brian learns to build his treatments into his daily routine

CF Life Lessons: My mindset prevented me from seeing the true impact of CF, or how important my treatments really are

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CF Life Lessons: Once you find a routine, your medications just become part of your life, and they don't become so much a of a burden

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CF Life Lessons: It gets hard to stay on top of your medications, especially if you don't understand the impact that CF can have

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Emily looks back at her CF during her youth

CF Life Lessons: I wish I had been better about doing my CF treatments

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CF Life Lessons: I am taking all of my treatments and redefining normal

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CF Life Lessons: Each treatment is a fraction of my fight against CF

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The effect of Pulmozyme on exercise tolerance has not been established in adults or children. Please see the full Prescribing Information for Important Safety Information.

The Importance of CF Treatments

Learn about other CF treatments and Pulmozyme

Understanding cystic fibrosis treatments

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How to take Pulmozyme

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Helpful CF resources and printouts

Image of Pulmozyme Doctor Discussion Guide

Discussing Pulmozyme With Your Doctor

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Image of Guide to taking Pulmozyme

How To Take Pulmozyme

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Daily Tips Beyond Your CF Treatment

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Indication and Usage

Pulmozyme (dornase alfa) is indicated for daily administration along with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Important Safety Information

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion, and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

Pediatric Use

The safety and effectiveness of Pulmozyme have been established in patients 5 years of age and older. While clinical trial data are limited in patients younger than 5 years of age, the use of Pulmozyme should be considered for pediatric CF patients who may experience potential benefit in lung function or who may be at risk of respiratory tract infection.

The safety of Pulmozyme given by daily inhalation for 2 weeks has been studied using 98 CF patients with 65 of them aged 3 months to <5 years (younger group) and 33 aged 5 years to <10 years (older group). The PARI BABY™ reusable nebulizer (which uses a face mask instead of a mouthpiece) was used in patients who were unable to show that they could breathe in or out using their mouth throughout the entire treatment period. Overall, the kind of side effects observed in children was similar to those seen in larger trials in older patients.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or You may also report side effects to Genentech at 1-888-835-2555.

For additional Important Safety Information, please click here for the Pulmozyme full Prescribing Information. If you have questions, please discuss them with your CF Care Team.