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Indication and Usage

Daily administration of Pulmozyme® (dornase alfa) Inhalation Solution along with standard therapies is indicated in the management of cystic fibrosis patients to improve lung function. In patients with a forced vital capacity (volume of air exhaled with maximum effort and speed) greater than or equal to 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring the administration of injectable antibiotics.

In our pivotal study, safety and efficacy of daily administration has not been studied in patients beyond 12 months.

Important Safety Information

  • Pulmozyme should not be used in patients who are allergic to any of its ingredients. Pulmozyme should be used along with standard therapies for cystic fibrosis.
  • When starting Pulmozyme therapy, patients may experience change in or loss of their voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose.
  • These side effects are usually mild and short-lived.

For further information, please see the Pulmozyme full Prescribing Information. If you have questions, please discuss them with your CF healthcare team.

Cystic Fibrosis Resource Center

Having the right information puts you in control.

Genentech® supports you and the CF community, and we provide a wealth of resources to help you in your fight against CF.

Pulmozyme Financial Support

We are committed to making sure you get the medicine you need. Pulmozyme Access Solutions provides a range of financial and support services to all eligible patients.

CF Living

This online community is a place for CF patients and caregivers to get advice, share stories and learn about others fighting this disease.

Pulmozyme FAQs

Learn more about cystic fibrosis, Pulmozyme treatment, potential side effects, insurance coverage and more.

Cystic Fibrosis Links

Browse a list of resources, including national organizations and support groups, that may be helpful to you and your family.


Find definitions of specialized terms related to cystic fibrosis and cystic fibrosis treatment.