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Indication and Usage

Daily administration of Pulmozyme® (dornase alfa) Inhalation Solution along with standard therapies is indicated in the management of cystic fibrosis patients to improve lung function. In patients with a forced vital capacity (volume of air exhaled with maximum effort and speed) greater than or equal to 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring the administration of injectable antibiotics.

In our pivotal study, safety and efficacy of daily administration has not been studied in patients beyond 12 months.

Important Safety Information

  • Pulmozyme should not be used in patients who are allergic to any of its ingredients. Pulmozyme should be used along with standard therapies for cystic fibrosis.
  • When starting Pulmozyme therapy, patients may experience change in or loss of their voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose.
  • These side effects are usually mild and short-lived.

For further information, please see the Pulmozyme full Prescribing Information. If you have questions, please discuss them with your CF healthcare team.

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1-888-PLMZYME (756-9963)

Pulmozyme Access Solutions®

Pulmozyme FAQs

Get answers to common questions about Pulmozyme below. For more information about Pulmozyme, speak to your doctor or call 1-888-PLMZYME (756-9963) to speak live with one of our specialists.

1. Why should Pulmozyme be a part of my CF treatment plan?

Pulmozyme may be an essential part of your fight against CF because it has been shown to improve lung function and reduce the risk of respiratory tract infection in mild to moderate disease.*

* Patients had an FVC ≥40% predicted. FVC stands for forced vital capacity, a test that shows how well the lungs work. To do the test, patients usually take the deepest breath they can. Then they exhale into a sensor for as long as they can. The amount of air they exhale is their FVC score.

2. How does Pulmozyme work?

CF is a complicated disease that leads to the body producing extra thick, sticky mucus. Pulmozyme uniquely targets one of the causes for such mucus: extracellular DNA.

Picture how a pair of cutters can be used to cut something into smaller pieces. Similarly, laboratory studies have shown that Pulmozyme cuts apart extracellular DNA by acting like an enzyme found naturally in the body. Cutting up extracellular DNA can help thin mucus.

3. What is extracellular DNA and how can it affect my mucus?

You may know DNA as the code used to build the cells in your body. So you might be wondering how DNA can be a problem for mucus in the lungs.

Because of CF, bacteria can build up in extra thick, sticky mucus. White blood cells fight the bacteria, leaving behind a substance called extracellular DNA. The extracellular DNA can make mucus more thick and sticky. Cutting it up can help thin mucus.

4. Will I feel better after taking Pulmozyme?

You may not feel better symptomatically, but Pulmozyme has been shown to improve lung function.

5. What if I can't fit my Pulmozyme treatment in every day?

Finding the time and place to take your treatments, like Pulmozyme, can feel difficult. No one is perfect. But having a routine that fits your lifestyle can help you stay in control.

For ideas on how to create a routine that fits your day-to-day needs, visit CFLiving.com. Your doctor, CF Care Team, and family can also help you explore ways to build treatment time into your lifestyle.

6. How does Pulmozyme work with my other medicines to help treat my CF?

Treating CF is complicated. So your doctor will prescribe other medicines to take in addition to Pulmozyme. These other medicines can include:

  • Hydrators—increase moisture in thick, sticky mucus
  • Antibiotics—prevent and treat infections
  • Bronchodilators—open airways

Pulmozyme works uniquely among medicines to help thin and loosen mucus.

7. Is Pulmozyme safe?

Pulmozyme has a demonstrated safety profile.

  • Pulmozyme should not be used in patients who are allergic to any of its ingredients.
  • Pulmozyme should be used along with standard therapies for cystic fibrosis.
  • When starting Pulmozyme therapy, patients may experience change in or loss of their voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose. These side effects are usually mild and short-lived.

Pulmozyme is approved by the FDA to be used with other standard CF treatments. Pulmozyme also has a safety profile in children, adolescents, and adults.*

* To learn more about the possible side effects that can happen with Pulmozyme, please read the Adverse Reactions section in the Prescribing Information. Because of the limited experience with the administration of Pulmozyme to patients younger than 5 years of age, its use should be considered only for those patients in whom there is a potential benefit in lung function or risk of respiratory infections.

8. What are the possible side effects of Pulmozyme?

You may feel more prepared if you talk to your doctor about what to expect when you begin Pulmozyme. Based on studies, patients taking Pulmozyme may experience change in or loss of voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose. These side effects are usually mild and short-lived. You should call your doctor if any of these side effects are severe, get worse, or do not go away.

Please see the Important Safety Information located on this website.

9. Does everyone who has CF need to take Pulmozyme?

Pulmozyme is a commonly prescribed medicine for the treatment of CF. The Cystic Fibrosis Foundation recommends Pulmozyme for patients 6 years of age and older to:

  • Improve lung function, regardless of how sick one may be
  • Reduce serious infections in mild to moderate disease

You and your doctor can discuss if Pulmozyme is right for you.

10. Should I store Pulmozyme?

Each sterile, single-use ampule of Pulmozyme (2.5 mg) is packaged in a protective foil pouch. The ampules should be left in their foil package and stored in the refrigerator. They should also be kept away from strong light.

11. Can I use just part of my Pulmozyme ampule and save the rest for later?

Pulmozyme comes in sterile, single-use ampules that should be used completely. Because Pulmozyme has no preservatives, the entire contents must be used or discarded.

12. Does Pulmozyme expire?

There are expiration dates stamped on each ampule. It is important to follow the stamped date and discard any ampules that expire.

13. Can I use the nebulizer/compressor I already have to take Pulmozyme?

The FDA approves specific nebulizers/compressors to be used with Pulmozyme.

The following nebulizers/compressors have been FDA-approved for use with Pulmozyme:

  • Durable Sidestream®* with MOBILAIRE™
  • Durable Sidestream®* with Porta-Neb®
  • Hudson "T" Up-draft II® with Pulmo-Aide®
  • Marquest Acorn II® with Pulmo-Aide®
  • PARI LC® PLUS Reusable* with PARI PRONEB®
  • PARI BABY™* with PARI PRONEB®

Your doctor can work with you to help you determine which of these approved systems are right for you.

14. I'm worried about being able to afford Pulmozyme. Is there anything I can do?

Pulmozyme Access Solutions® can connect you to the medicine you need. If you are worried about paying for Pulmozyme, we are here to help.

Whether you have healthcare coverage or not, we can help you by:

  • Finding out if your healthcare plan pays for your medicines
  • Guiding you through the process of getting your medicine
  • Connecting you with our patient assistance programs

To learn more about how we can help, contact us. Call 1-800-690-3023 to speak live with one of our Specialists. You can also visit PulmozymeAccessSolutions.com.

15. Where can I find more information about CF or Pulmozyme online?

The CF community is active and information can be just a click away.

  • CFF.org is the Cystic Fibrosis Foundation's website, where you'll find information on CF and get connected to the greater CF community.
  • PulmozymeAccessSolutions.com can help patients whose plans don't pay for Pulmozyme. They offer programs to help you access Pulmozyme, regardless of your ability to pay.
  • CFLiving.com connects you to personalized support and tips that can help you stick with your medicines, like Pulmozyme. You can listen to stories from peers, get lifestyle tips, and so much more.

Please see Important Safety Information and accompanying full
Prescribing Information.