Nebulizers and How to Take Pulmozyme® (dornase alfa) CF Treatment

How to take Pulmozyme

Before taking your Pulmozyme, it is important to receive training from your cystic fibrosis (CF) Care Team. You will need the following items for taking Pulmozyme:

Dose of pulmozyme

One ampule of Pulmozyme

What are my options for taking Pulmozyme?

Several nebulizer and compressor combinations are FDA-approved.

One nebulizer system is FDA-approved.

Jet Nebulizers+CompressorsNebulizer System
Hudson T Up-draft II® withPulmo-Aide®

eRapid® (PARI) Nebulizer System

The eRapid system delivers short treatment times in a system that is small, portable, quiet, and quick‡

For more information on eRapid, call PARI at (866) 335-6943, or visit

Marquest Acorn II® withPulmo-Aide®
Durable Sidestream® withMOBILAIRE
Durable Sidestream® withPorta-Neb®

Talk to your doctor about which nebulizer is right for you

*Patients who are unable to inhale or exhale orally through the entire nebulization period may use the PARI BABY nebulizer.

Consisting of the eRapid® Nebulizer Handset with eBase Controller.

The average nebulization time for the eRapid Nebulizer System is approximately 2-3 minutes compared to the LC® Plus Jet Nebulizer, which is
6-10 minutes.

Learn more about CF ›

Indication and Usage

Pulmozyme (dornase alfa) is indicated for daily administration along with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Important Safety Information

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion, and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

Pediatric Use

The safety and effectiveness of Pulmozyme have been established in patients 5 years of age and older. While clinical trial data are limited in patients younger than 5 years of age, the use of Pulmozyme should be considered for pediatric CF patients who may experience potential benefit in lung function or who may be at risk of respiratory tract infection.

The safety of Pulmozyme given by daily inhalation for 2 weeks has been studied using 98 CF patients with 65 of them aged 3 months to <5 years (younger group) and 33 aged 5 years to <10 years (older group). The PARI BABY™ reusable nebulizer (which uses a face mask instead of a mouthpiece) was used in patients who were unable to show that they could breathe in or out using their mouth throughout the entire treatment period. Overall, the kind of side effects observed in children was similar to those seen in larger trials in older patients.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or You may also report side effects to Genentech at 1-888-835-2555.

For additional Important Safety Information, please click here for the Pulmozyme full Prescribing Information. If you have questions, please discuss them with your CF Care Team.