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Indication

Pulmozyme® (dornase alfa) is indicated for daily administration along with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Important Safety Information

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

For further information, please see the Pulmozyme full Prescribing Information.

Pediatric Use

The safety and effectiveness of Pulmozyme have been established in patients 5 years of age and older. While clinical trial data are limited in patients younger than 5 years of age, the use of PULMOZYME should be considered for pediatric CF patients who may experience potential benefit in lung function or who may be at risk of respiratory tract infection.

The safety of Pulmozyme given by daily inhalation for 2 weeks has been studied using 98 CF patients with 65 of them aged 3 months to <5 years (younger group) and 33 aged 5 years to <10 years (older group). The PARI BABY™ reusable nebulizer (which uses a face mask instead of a mouthpiece) was used in patients who were unable to show that they could breathe in or out using their mouth throughout the entire treatment period. Overall, the kind of side effects observed in children was similar to those seen in larger trials in older patients.

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Pulmozyme Access Solutions®

Taking Pulmozyme

Every day matters.

Even when symptoms aren't present, cystic fibrosis is still present. That's why taking Pulmozyme every day, along with other standard therapies, is so important.

Pulmozyme may be an essential part in your fight against cystic fibrosis (CF).

Pulmozyme works uniquely among CF medicines. It targets extracellular DNA to help keep mucus thin and loose, and goes straight to work in your lungs, where it is needed most. In those with mild to moderate CF*, Pulmozyme may be an essential part in the fight against CF, as it may help improve lung function and reduce the risk of respiratory tract infection. For more information on how Pulmozyme works,
click here.

Pulmozyme Study

When starting Pulmozyme therapy, patients may experience change in or loss of voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose. These side effects are usually mild and short-lived.

* Patients had an FVC ≥40% predicted. FVC stands for forced vital capacity, a test that shows how well the lungs work. To do the test, patients usually take the deepest breath they can. Then they exhale into a sensor for as long as they can. The amount of air they exhale is their FVC score.

Find effective ways to make time for treatment.

Finding the time and place to take your treatments, including Pulmozyme, can feel difficult. No one is perfect. But establishing and sticking to a routine that fits your lifestyle can help you stay in control. Here are some tips to consider that might help you work treatment time into your lifestyle.

  • Create a routine that fits your day-to-day needs
  • Try reminders, like notes or alarms
  • Put your CF stuff where it can be seen and easily accessed

Looking for more ways to make your or your child's Pulmozyme treatment time more interesting? Visit CFLiving.com for advice on living with CF, tips and suggestions for fitting treatment into daily life and more. As always, be sure to talk to your doctor and CF Care Team about any questions you may have.