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1-888-PLMZYME (756-9963)

Indication

Pulmozyme® (dornase alfa) is indicated for daily administration along with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Important Safety Information

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

For further information, please see the Pulmozyme full Prescribing Information.

Pediatric Use

The safety and effectiveness of Pulmozyme have been established in patients 5 years of age and older. While clinical trial data are limited in patients younger than 5 years of age, the use of PULMOZYME should be considered for pediatric CF patients who may experience potential benefit in lung function or who may be at risk of respiratory tract infection.

The safety of Pulmozyme given by daily inhalation for 2 weeks has been studied using 98 CF patients with 65 of them aged 3 months to <5 years (younger group) and 33 aged 5 years to <10 years (older group). The PARI BABY™ reusable nebulizer (which uses a face mask instead of a mouthpiece) was used in patients who were unable to show that they could breathe in or out using their mouth throughout the entire treatment period. Overall, the kind of side effects observed in children was similar to those seen in larger trials in older patients.

Customer Contact Center

1-888-PLMZYME (756-9963)

Pulmozyme Access Solutions®

How to take Pulmozyme

Before taking or administering Pulmozyme, it is important to receive training from your CF healthcare team. You will need the following items for Pulmozyme administration:

  • One ampule of Pulmozyme
  • One nebulizer approved for use with Pulmozyme
  • Tubing and other components that come with the nebulizer
  • A mouthpiece (or a face mask for children younger than five years) and a compressor compatible with your nebulizer

It is important to take Pulmozyme every day as indicated by your doctor. This will ensure the highest level of efficacy in your fight against CF. Watch the following video for some helpful tips for taking Pulmozyme.

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Please see Important Safety Information

Follow these steps to administer Pulmozyme.

  1. Step 1

    • Pulmozyme Nebulizer Step 1
    • Begin by cleaning a flat table surface.
  2. Step 2

    • Pulmozyme Nebulizer Step 2
    • Always wash your hands thoroughly with soap and water before preparing the medication. This will avoid the risk of germs being introduced into the system.
  3. Step 3

    • Pulmozyme Nebulizer Step 3
    • Place the nebulizer system onto the clean surface. The system should be clean and ready for use.
  4. Step 4

    • Pulmozyme Nebulizer Step 4_1
      Pulmozyme Nebulizer Step 4_2
    • Test the compressor by turning it on, and feeling the air output by putting your finger in front of the air output port. Turn the compressor off.
  5. Step 5

    • Pulmozyme Nebulizer Step 5_1
    • Remove one ampule of Pulmozyme from its package. Look at the expiration date. Look at the contents of the solution to ensure clarity.
    • Pulmozyme Nebulizer Step 5_2
    • If the solution is cloudy or discolored, do not use it. Turn the ampule upside down and squeeze gently to ensure a leak is not present.
  6. Step 6

    • Pulmozyme Nebulizer Step 6_1
    • Attach the tubing to the air output nozzle of the compressor.
    • Pulmozyme Nebulizer Step 5_2
    • Attach the other end to the bottom of the nebulizer.
  7. Step 7

    • Pulmozyme Nebulizer Step 7_1
    • Twist the top off the ampule of Pulmozyme
    • Pulmozyme Nebulizer Step 7_2
    • Empty the contents into the medicine cup of the nebulizer.
  8. Step 8

    • Pulmozyme Nebulizer Step 8_1
    • Now, attach the mouthpiece or face mask to the nebulizer.
    • Pulmozyme Nebulizer Step 8_2
    • Check to ensure the tubing is properly connected to the bottom of the nebulizer.
    • Pulmozyme Nebulizer Step 8_3
    • Turn the compressor on. You should see mist being generated.
  9. Step 9

    • Pulmozyme Nebulizer Step 9_1
    • The mouthpiece should be placed between teeth and tongue. The tongue should not block the flow of medicine.
    • Pulmozyme Nebulizer Step 9_2
    • Take slow, deep breaths, making sure to avoid nose breathing.
  10. Step 10

    • Pulmozyme Nebulizer Step 10_1
    • Toward the end of the treatment when the nebulizer begins spitting, gently tap the medicine cup to ensure all medicine has been used.
    • Pulmozyme Nebulizer Step 10_2
    • When the mist subsides, your treatment is complete.

    For answers to common questions about how Pulmozyme works, please visit our FAQ page.

Commit to your care.

We often hear patients say that their nebulizers can be an unwanted reminder of CF. Want to learn ways to include treatment in your day so that it's more like a routine than a reminder? Visit CFLiving.com for tips and advice. Your doctor can also help you find ways to fit treatment time into your schedule and lifestyle.