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Indication and Usage

Daily administration of Pulmozyme® (dornase alfa) Inhalation Solution along with standard therapies is indicated in the management of cystic fibrosis patients to improve lung function. In patients with a forced vital capacity (volume of air exhaled with maximum effort and speed) greater than or equal to 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring the administration of injectable antibiotics.

In our pivotal study, safety and efficacy of daily administration has not been studied in patients beyond 12 months.

Important Safety Information

  • Pulmozyme should not be used in patients who are allergic to any of its ingredients. Pulmozyme should be used along with standard therapies for cystic fibrosis.
  • When starting Pulmozyme therapy, patients may experience change in or loss of their voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose.
  • These side effects are usually mild and short-lived.

For further information, please see the Pulmozyme full Prescribing Information. If you have questions, please discuss them with your CF healthcare team.

Customer Contact Center

1-888-PLMZYME (756-9963)

Pulmozyme Access Solutions®

How to take Pulmozyme

Before taking or administering Pulmozyme, it is important to receive training from your CF healthcare team. You will need the following items for Pulmozyme administration:

  • One ampule of Pulmozyme
  • One nebulizer approved for use with Pulmozyme
  • Tubing and other components that come with the nebulizer
  • A mouthpiece (or a face mask for children younger than five years) and a compressor compatible with your nebulizer

It is important to take Pulmozyme every day as indicated by your doctor. This will ensure the highest level of efficacy in your fight against CF. Watch the following video for some helpful tips for taking Pulmozyme.

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Please see Important Safety Information

Follow these steps to administer Pulmozyme.

  1. Step 1

    • Pulmozyme Nebulizer Step 1
    • Begin by cleaning a flat table surface.
  2. Step 2

    • Pulmozyme Nebulizer Step 2
    • Always wash your hands thoroughly with soap and water before preparing the medication. This will avoid the risk of germs being introduced into the system.
  3. Step 3

    • Pulmozyme Nebulizer Step 3
    • Place the nebulizer system onto the clean surface. The system should be clean and ready for use.
  4. Step 4

    • Pulmozyme Nebulizer Step 4_1
      Pulmozyme Nebulizer Step 4_2
    • Test the compressor by turning it on, and feeling the air output by putting your finger in front of the air output port. Turn the compressor off.
  5. Step 5

    • Pulmozyme Nebulizer Step 5_1
    • Remove one ampule of Pulmozyme from its package. Look at the expiration date. Look at the contents of the solution to ensure clarity.
    • Pulmozyme Nebulizer Step 5_2
    • If the solution is cloudy or discolored, do not use it. Turn the ampule upside down and squeeze gently to ensure a leak is not present.
  6. Step 6

    • Pulmozyme Nebulizer Step 6_1
    • Attach the tubing to the air output nozzle of the compressor.
    • Pulmozyme Nebulizer Step 5_2
    • Attach the other end to the bottom of the nebulizer.
  7. Step 7

    • Pulmozyme Nebulizer Step 7_1
    • Twist the top off the ampule of Pulmozyme
    • Pulmozyme Nebulizer Step 7_2
    • Empty the contents into the medicine cup of the nebulizer.
  8. Step 8

    • Pulmozyme Nebulizer Step 8_1
    • Now, attach the mouthpiece or face mask to the nebulizer.
    • Pulmozyme Nebulizer Step 8_2
    • Check to ensure the tubing is properly connected to the bottom of the nebulizer.
    • Pulmozyme Nebulizer Step 8_3
    • Turn the compressor on. You should see mist being generated.
  9. Step 9

    • Pulmozyme Nebulizer Step 9_1
    • The mouthpiece should be placed between teeth and tongue. The tongue should not block the flow of medicine.
    • Pulmozyme Nebulizer Step 9_2
    • Take slow, deep breaths, making sure to avoid nose breathing.
  10. Step 10

    • Pulmozyme Nebulizer Step 10_1
    • Toward the end of the treatment when the nebulizer begins spitting, gently tap the medicine cup to ensure all medicine has been used.
    • Pulmozyme Nebulizer Step 10_2
    • When the mist subsides, your treatment is complete.

    For answers to common questions about how Pulmozyme works, please visit our FAQ page.

Commit to your care.

We often hear patients say that their nebulizers can be an unwanted reminder of CF. Want to learn ways to include treatment in your day so that it's more like a routine than a reminder? Visit for tips and advice. Your doctor can also help you find ways to fit treatment time into your schedule and lifestyle.