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Indication and Usage

Daily administration of Pulmozyme® (dornase alfa) Inhalation Solution along with standard therapies is indicated in the management of cystic fibrosis patients to improve lung function. In patients with a forced vital capacity (volume of air exhaled with maximum effort and speed) greater than or equal to 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring the administration of injectable antibiotics.

In our pivotal study, safety and efficacy of daily administration has not been studied in patients beyond 12 months.

Important Safety Information

  • Pulmozyme should not be used in patients who are allergic to any of its ingredients. Pulmozyme should be used along with standard therapies for cystic fibrosis.
  • When starting Pulmozyme therapy, patients may experience change in or loss of their voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose.
  • These side effects are usually mild and short-lived.

For further information, please see the Pulmozyme full Prescribing Information. If you have questions, please discuss them with your CF healthcare team.

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Understanding Cystic Fibrosis

You fight it every day—be sure to fight it in every way.

Cystic fibrosis (CF) is a complicated genetic disease that causes your body to produce extra-thick, sticky mucus. If you or your loved one is fighting this disease, they may require medicines as part of their treatment routine. Because not all medicines work the same or address the same symptoms, a combination of medications may be needed.

Pulmozyme is a commonly prescribed CF medicine that uniquely targets one of the causes for such mucus: extracellular DNA. In order to understand how Pulmozyme targets extracellular DNA, picture how a pair of scissors can be used to cut something into smaller pieces. Similarly, laboratory studies have shown that Pulmozyme cuts apart extracellular DNA by acting like an enzyme* found naturally in the body.

Your doctor and CF Care Team want you to have treatment that keeps you as healthy as possible. Being open about your questions or concerns can help you and your doctor make the right treatment decisions for your fight against CF. Continue reading through the next sections to find out more about how Pulmozyme may help you in your fight against CF.

For more information about cystic fibrosis, visit the Cystic Fibrosis Foundation at

* Enzymes are proteins created by the body to help speed up chemical reactions (such as the breakdown of molecules).