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Indication and Usage

Daily administration of Pulmozyme® (dornase alfa) Inhalation Solution along with standard therapies is indicated in the management of cystic fibrosis patients to improve lung function. In patients with a forced vital capacity (volume of air exhaled with maximum effort and speed) greater than or equal to 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring the administration of injectable antibiotics.

In our pivotal study, safety and efficacy of daily administration has not been studied in patients beyond 12 months.

Important Safety Information

  • Pulmozyme should not be used in patients who are allergic to any of its ingredients. Pulmozyme should be used along with standard therapies for cystic fibrosis.
  • When starting Pulmozyme therapy, patients may experience change in or loss of their voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose.
  • These side effects are usually mild and short-lived.

For further information, please see the Pulmozyme full Prescribing Information. If you have questions, please discuss them with your CF healthcare team.

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The Cycle of Cystic Fibrosis Progression

Understanding Cystic Fibrosis

Left untreated, cystic fibrosis can drastically affect the health of the patient. Be sure to talk to your doctor if you have questions about how cystic fibrosis is affecting your health or the health of a loved one.

Cystic fibrosis often develops through the following stages:

  • Obstruction: Thick, sticky mucus blocks the airways. This means it's harder for the lungs to remove bacteria from the lungs, which leads to…
  • Respiratory tract infection: Thickened mucus also creates an environment for bacteria to grow, which leads to…
  • Inflammation: Inflammation is a part of the body's reaction to infection. Neutrophils enter the lungs to fight infection. These neutrophils leave behind DNA, which makes mucus even stickier and leads to…
  • More obstruction, more infection and more inflammation

Cystic fibrosis progression

While there is no cure for CF, you have treatment options that may help. Your doctor likely will also prescribe additional medicines to Pulmozyme to address other symptoms of cystic fibrosis. These can help to increase moisture in the mucus, prevent and treat infections, and open airways.

Please see Important Safety Information and accompanying full
Prescribing Information.