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Indication

Pulmozyme® (dornase alfa) is indicated for daily administration along with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Important Safety Information

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

For further information, please see the Pulmozyme full Prescribing Information.

Pediatric Use

The safety and effectiveness of Pulmozyme have been established in patients 5 years of age and older. While clinical trial data are limited in patients younger than 5 years of age, the use of PULMOZYME should be considered for pediatric CF patients who may experience potential benefit in lung function or who may be at risk of respiratory tract infection.

The safety of Pulmozyme given by daily inhalation for 2 weeks has been studied using 98 CF patients with 65 of them aged 3 months to <5 years (younger group) and 33 aged 5 years to <10 years (older group). The PARI BABY™ reusable nebulizer (which uses a face mask instead of a mouthpiece) was used in patients who were unable to show that they could breathe in or out using their mouth throughout the entire treatment period. Overall, the kind of side effects observed in children was similar to those seen in larger trials in older patients.

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Pulmozyme Access Solutions®

The Cycle of Cystic Fibrosis Progression

Understanding Cystic Fibrosis

Left untreated, cystic fibrosis can drastically affect the health of the patient. Be sure to talk to your doctor if you have questions about how cystic fibrosis is affecting your health or the health of a loved one.

Cystic fibrosis often develops through the following stages:

  • Obstruction: Thick, sticky mucus blocks the airways. This means it's harder for the lungs to remove bacteria from the lungs, which leads to…
  • Respiratory tract infection: Thickened mucus also creates an environment for bacteria to grow, which leads to…
  • Inflammation: Inflammation is a part of the body's reaction to infection. Neutrophils enter the lungs to fight infection. These neutrophils leave behind DNA, which makes mucus even stickier and leads to…
  • More obstruction, more infection and more inflammation

Cystic fibrosis progression

While there is no cure for CF, you have treatment options that may help. Your doctor likely will also prescribe additional medicines to Pulmozyme to address other symptoms of cystic fibrosis. These can help to increase moisture in the mucus, prevent and treat infections, and open airways.

Please see Important Safety Information and accompanying full
Prescribing Information.