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Indication and Usage

Daily administration of Pulmozyme® (dornase alfa) Inhalation Solution along with standard therapies is indicated in the management of cystic fibrosis patients to improve lung function. In patients with a forced vital capacity (volume of air exhaled with maximum effort and speed) greater than or equal to 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring the administration of injectable antibiotics.

In our pivotal study, safety and efficacy of daily administration has not been studied in patients beyond 12 months.

Important Safety Information

  • Pulmozyme should not be used in patients who are allergic to any of its ingredients. Pulmozyme should be used along with standard therapies for cystic fibrosis.
  • When starting Pulmozyme therapy, patients may experience change in or loss of their voice, discomfort in the throat, chest pain, red watery eyes, rash, dizziness, fever, or runny nose.
  • These side effects are usually mild and short-lived.

For further information, please see the Pulmozyme full Prescribing Information. If you have questions, please discuss them with your CF healthcare team.

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Pulmozyme Access Solutions®

Normal vs Abnormal Mucus and Cystic Fibrosis

CF is a disease that gets worse over time. There is no cure, but there are treatment options that may help. Learn why lungs produce mucus in the first place, and what happens when they produce too much.

What's the difference?

The lungs naturally produce a layer of mucus that protects them. In healthy lungs, mucus helps keep bacteria on the move so they don't linger and cause
respiratory tract infection.

For people living with CF, however, the mucus is thicker than normal. The body also produces more mucus than usual. The thick, sticky mucus in the lungs obstructs airways and allows bacterial infection and inflammation to occur. White blood cells, called neutrophils, are sent to fight these infections.

Sticky mucus and cystic fibrosis

Sticky mucus contributes to the progression of
Cystic Fibrosis over time

In the process of fighting these infections, white blood cells leave behind remains called extracellular DNA that can make mucus extra thick and sticky. Ordinarily mucus would clear these "leftovers" (i.e., extracellular DNA) from the lungs. When it can't, some of these leftover remains can cause damage to the lungs. The DNA left behind makes the mucus even thicker and stickier, which leaves your lungs even more vulnerable to damage.