Your patients and/or their caregivers will likely have questions about how to administer Pulmozyme. Each Pulmozyme treatment, dosed QD or BID, requires the following items1:
Jet Nebulizers | + Compressors |
---|---|
Hudson T Up-draft II® with | Pulmo-Aide® |
Marquest Acorn II® with | Pulmo-Aide® |
PARI LC® Plus | PARI PRONEB® |
*PARI BABY™ | PARI PRONEB® |
Durable Sidestream® with | MOBILAIRE™ |
Durable Sidestream® with | Porta-Neb® |
*Patients who are unable to inhale or exhale orally through the entire nebulization period may use the PARI BABY™ nebulizer.
†Consisting of the eRapid® Nebulizer Handset with eBase™ Controller.
‡The average nebulization time for the eRapid Nebulizer System is approximately 2-3 minutes compared to the LC® Plus Jet Nebulizer, which is 6-10 minutes.
A step-by-step guide to taking Pulmozyme, including a list of equipment needed.
Patients may want to consider what conveniences they need. For example, nebulizers/compressors may have different delivery times and cleaning instructions.
Certain nebulizers are designed especially for younger children and have features such as a mask instead of a mouthpiece.
Costs, out-of-pocket expenses, and insurance coverage can vary.
If you are considering eRapid for your patient, visit www.PARI.com to locate specialty pharmacies that distribute eRapid.
Have your patients download patient-friendly, step-by-step instructions on administering Pulmozyme.1
Pulmozyme [package insert]. South San Francisco, CA: Genentech, Inc; 2018.
Pulmozyme [package insert]. South San Francisco, CA: Genentech, Inc; 2018.
Harms HK, Matouk E, Tournier G, et al; DNase International Study Group. Multicenter, open-label study of recombinant human DNase in cystic fibrosis patients with moderate lung disease. Pediatr Pulmonol. 1998;26(3):155-161.
Harms HK, Matouk E, Tournier G, et al; DNase International Study Group. Multicenter, open-label study of recombinant human DNase in cystic fibrosis patients with moderate lung disease. Pediatr Pulmonol. 1998;26(3):155-161.
Chmiel JF, Konstan MW. Anti-inflammatory medications for cystic fibrosis lung disease: selecting the most appropriate agent. Treat Respir Med. 2005;4(4):255-273.
Chmiel JF, Konstan MW. Anti-inflammatory medications for cystic fibrosis lung disease: selecting the most appropriate agent. Treat Respir Med. 2005;4(4):255-273.
Puchelle E, de Bentzmann S, Zahm JM. Physical and functional properties of airway secretions in cystic fibrosis—therapeutic approaches. Respiration. 1995;62(suppl 1):2-12.
Puchelle E, de Bentzmann S, Zahm JM. Physical and functional properties of airway secretions in cystic fibrosis—therapeutic approaches. Respiration. 1995;62(suppl 1):2-12.
King M. Mucolytics and mucus clearance. In: Rubin BK, van der Schans CP, eds. Therapy for Mucus-Clearance Disorders. New York, NY: Marcel Dekker Inc; 2004:201-224.
King M. Mucolytics and mucus clearance. In: Rubin BK, van der Schans CP, eds. Therapy for Mucus-Clearance Disorders. New York, NY: Marcel Dekker Inc; 2004:201-224.
Flume PA, Van Devanter DR. State of progress in treating cystic fibrosis respiratory disease. BMC Med. 2012;10:88.
Flume PA, Van Devanter DR. State of progress in treating cystic fibrosis respiratory disease. BMC Med. 2012;10:88.
Drug development pipeline. Cystic Fibrosis Foundation website. https://www.cff.org/trials/pipeline. Accessed August 17, 2020.
Drug development pipeline. Cystic Fibrosis Foundation website. https://www.cff.org/trials/pipeline. Accessed August 17, 2020.
Research milestones. Cystic Fibrosis Foundation website. https://www.cff.org/Our-Research/Our-Research-Approach/Research-Milestones. August 17, 2020.
Research milestones. Cystic Fibrosis Foundation website. https://www.cff.org/Our-Research/Our-Research-Approach/Research-Milestones. August 17, 2020.
Fuchs HJ, Borowitz DS, Christiansen DH, et al. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. N Engl J Med. 1994;331(10):637-642.
Fuchs HJ, Borowitz DS, Christiansen DH, et al. Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. N Engl J Med. 1994;331(10):637-642.
Data on file. Genentech, a member of the Roche Group.
Data on file. Genentech, a member of the Roche Group.
Cystic Fibrosis Foundation Patient Registry 2016 Annual Data Report. Bethesda, MD. ©2017 Cystic Fibrosis Foundation.
Cystic Fibrosis Foundation Patient Registry 2016 Annual Data Report. Bethesda, MD. ©2017 Cystic Fibrosis Foundation.
Sly PD, Brennan S, Gangell C, et al. Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. Am J Respir Crit Care Med. 2009;180(2):146-152.
Sly PD, Brennan S, Gangell C, et al. Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening. Am J Respir Crit Care Med. 2009;180(2):146-152.
Sly PD, Gangell CL, Chen L, et al. Risk factors for bronchiectasis in children with cystic fibrosis. N Engl J Med. 2013;368(21):1963-1970.
Sly PD, Gangell CL, Chen L, et al. Risk factors for bronchiectasis in children with cystic fibrosis. N Engl J Med. 2013;368(21):1963-1970.
Bakker EM, Volpi S, Salonini E, et al. Small airway deposition of dornase alfa during exacerbations in cystic fibrosis; a randomized controlled clinical trial. Pediatr Pulmonol. 2020;49(2):154-161.
Bakker EM, Volpi S, Salonini E, et al. Small airway deposition of dornase alfa during exacerbations in cystic fibrosis; a randomized controlled clinical trial. Pediatr Pulmonol. 2020;49(2):154-161.
Trikafta [Package insert]. Boston, MA: Vertex Pharmaceuticals Incorporated; 2019.
Trikafta [Package insert]. Boston, MA: Vertex Pharmaceuticals Incorporated; 2019.
Heijerman HGM, McKone EF, Downey DG, et al. Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial. Lancet. 2019;394(10212)1940-1948.
Heijerman HGM, McKone EF, Downey DG, et al. Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial. Lancet. 2019;394(10212)1940-1948.
Middleton PG, Mall MA, Dřevínek P, et al. Elexacaftor–tezacaftor–ivacaftor for cystic fibrosis with a single Phe508del allele. N Engl J Med. 2019;381(19):1809-1819.
Middleton PG, Mall MA, Dřevínek P, et al. Elexacaftor–tezacaftor–ivacaftor for cystic fibrosis with a single Phe508del allele. N Engl J Med. 2019;381(19):1809-1819.
Pulmozyme Instructions for Use. South San Francisco, CA: Genentech, Inc; 2018.
Pulmozyme Instructions for Use. South San Francisco, CA: Genentech, Inc; 2018.
Non-US Residents visit: Pulmozyme.global
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