How Pulmozyme works to fight cystic fibrosis (CF)

It works to fight CF, even when you can’t feel it

In clinical studies, Pulmozyme made mucus thinner and looser, which can make it easier to clear your lungs. CF often requires several different medicines as part of a treatment routine. Not all medicines work the same, so your doctor will prescribe multiple therapies to help you fight CF.

How Pulmozyme works to fight cystic fibrosis

Laboratory studies show that Pulmozyme cuts apart extracellular DNA by acting like an enzyme* naturally found in the lungs. By cutting this extracellular DNA, Pulmozyme helps make the thick, sticky mucus that your lungs produce thinner and looser.


*Enzymes are proteins created by the body to help speed up chemical reactions (such as the breakdown of molecules).


Why is Pulmozyme important?

In cystic fibrosis, your lungs produce extra-thick, sticky mucus. In laboratory studies, Pulmozyme made this mucus thinner and looser.

Cystic Fibrosis (CF) mucus before Pulmozyme® (dornase alfa)
CF mucus before Pulmozyme
Cystic Fibrosis (CF) mucus after Pulmozyme® (dornase alfa)
CF mucus after Pulmozyme

A study of cystic fibrosis patients 5 years of age and older with a forced vital capacity (FVC) of greater than or equal to 40% of predicted found:

Lung infections

Patients taking Pulmozyme daily had a lower risk of developing lung infections requiring intravenous (IV) antibiotics and showed an improvement in lung function, compared with those not taking Pulmozyme.


Starting treatment with Pulmozyme

Before taking your Pulmozyme, it is important to receive training from your CF Care Team. Here's what you will need to get started:

  • Your Pulmozyme dose
  • Nebulizer
  • Compressor

Discussing Pulmozyme with your doctor

Use this Discussion Guide to help prepare for your doctor’s appointment and get the answers you’ll need for your everyday Pulmozyme treatment.

Financial assistance

Need help paying for Pulmozyme?

Get info on our financial support programs

Getting started with Pulmozyme® (dornase alfa)

Getting started on Pulmozyme?

Learn about what you need to do to prepare for treatment

Indication & Usage

Pulmozyme (dornase alfa) is indicated for daily administration along with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring injectable antibiotics.

Important Safety Information

Pulmozyme should not be used in patients who are allergic to any of its ingredients.

Patients may experience the following when using Pulmozyme: change in or loss of their voice, discomfort in the throat, rash, chest pain, red watery eyes, runny nose, lowering of lung function, fever, indigestion, and shortness of breath. There have been no reports of severe allergic reactions caused by the administration of Pulmozyme. Mild to moderate hives and mild skin rash have been observed and have been short-lived.

Pediatric Use

The safety and effectiveness of Pulmozyme have been established in patients 5 years of age and older. While clinical trial data are limited in patients younger than 5 years of age, the use of Pulmozyme should be considered for pediatric CF patients who may experience potential benefit in lung function or who may be at risk of respiratory tract infection.

The safety of Pulmozyme given by daily inhalation for 2 weeks has been studied using 98 CF patients with 65 of them aged 3 months to <5 years (younger group) and 33 aged 5 years to <10 years (older group). The PARI BABY™ reusable nebulizer (which uses a face mask instead of a mouthpiece) was used in patients who were unable to show that they could breathe in or out using their mouth throughout the entire treatment period. Overall, the kind of side effects observed in children was similar to those seen in larger trials in older patients.

You are encouraged to report side effects to Genentech and the FDA. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

Please see full Pulmozyme Prescribing Information for additional Important Safety Information. If you have questions, please discuss them with your CF Care Team.