Instructions for dosing and administering Pulmozyme in cystic fibrosis (CF) patients

Pulmozyme is available for once- or twice-daily administration1

  QD BID
Dose amount 2.5 mg 2.5 mg
Dose frequency Once per day Twice per day

The recommended dose for most patients with CF is 2.5 mg once daily (QD); however, some patients over 21 years of age may benefit from 2.5 mg twice-daily (BID) dosing to reduce exacerbation risk.1

Your patients and/or their caregivers will likely have questions about how to administer Pulmozyme (dornase alfa). Each Pulmozyme (dornase alfa) treatment, dosed QD or BID, requires the following items1:

  • One ampule of Pulmozyme (dornase alfa)1
    • Pulmozyme (dornase alfa) is supplied in single-use ampules. It should be stored under refrigeration and protected from strong light
  • One jet nebulizer approved for use with Pulmozyme (dornase alfa) that can be connected to an air compressor.18 Learn how to administer Jet Nebulizer
  • OR with a portable nebulizer like the eRapidTM Nebulizer System.18 Learn how to administer with portable nebulizer system
  • Tubing and other components that come with the nebulizer18
  • A mouthpiece or a face mask (for younger patients unable to inhale or exhale consistently using a mouthpiece)1

Remember to communicate these important instructions to patients/caregivers

  • Do not dilute or mix Pulmozyme (dornase alfa) with other drugs in the nebulizer
    • Mixing of Pulmozyme (dornase alfa) with other drugs could lead to adverse physicochemical and/or functional changes in Pulmozyme (dornase alfa) or the admixed compound
  • Follow the manufacturer's instructions on the use and maintenance of the equipment, including cleaning and disinfection procedures
Contact a Representative

Contact a representative

Call 1-866-422-2377 (6AM-5PM PT, Monday through Friday)

How Pulmozyme® (dornase alfa) Works - Mechanism of Action (MoA)

How Pulmozyme Works

Pulmozyme works to break up thick and sticky mucus in the lungs of people with CF

Indication and Usage

Pulmozyme (dornase alfa) is indicated for daily administration in conjunction with standard therapies for the management of cystic fibrosis (CF) patients to improve pulmonary function.

In CF patients with an FVC ≥ 40% of predicted, daily administration of Pulmozyme has also been shown to reduce the risk of respiratory tract infections requiring parenteral antibiotics.

Pulmozyme is contraindicated in patients with known hypersensitivity to dornase alfa, Chinese Hamster Ovary cell products, or any component of the product.

The most common adverse reactions associated with the use of Pulmozyme include: voice alteration, pharyngitis, rash, laryngitis, chest pain, conjunctivitis, rhinitis, decrease in FVC of ≥ 10%, fever, dyspepsia, and dyspnea. There have been no reports of anaphylaxis attributed to the administration of Pulmozyme. Mild to moderate urticaria and mild skin rash have been observed and have been transient.

Pediatric Use

The safety and effectiveness of Pulmozyme in conjunction with standard therapies for cystic fibrosis have been established in pediatric patients. Use of Pulmozyme in pediatric patients is supported by evidence in the following age groups:

  • Patients 5 to 17 years of age: A randomized, placebo-controlled trial of 303 of clinically stable cystic fibrosis patients 5 to 17 years of age who received Pulmozyme.
  • Patients less than 5 years: Extrapolation of efficacy data in patients 5 years of age and older with additional safety data in 65 pediatric patients aged 3 months to less than 5 years who received Pulmozyme 2.5 mg daily by inhalation for 2 weeks.

The safety of Pulmozyme, 2.5 mg by inhalation, was studied with 2 weeks of daily administration in 98 pediatric patients with cystic fibrosis 3 months to 10 years of age (65 aged 3 months to < 5 years, 33 aged 5 to ≤ 10 years). The PARI BABYTM reusable nebulizer (which uses a facemask instead of a mouthpiece) was utilized in patients unable to demonstrate the ability to inhale or exhale orally throughout the entire treatment period (54/65, 83% of the younger; and 2/33, 6% of the older patients). Overall, the nature of adverse reactions was similar to that seen in the placebo-controlled trials in older patients. The number of patients reporting cough was higher in the younger age group as compared to the older age group (29/65, 45%; compared to 10/33, 30%) as was the number reporting moderate to severe cough (24/65, 37%; compared to 6/33, 18%). The number of patients reporting rhinitis was higher in the younger age group as compared to the older age group (23/65, 35%; compared to 9/33, 27%) as was the number reporting rash (4/65, 6% as compared to 0/33, 0%).

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.

Please see Pulmozyme full Prescribing Information for additional Important Safety Information.

    • Pulmozyme (dornase alfa) [package insert]. South San Francisco, CA: Genentech, Inc; 2021.

      Pulmozyme (dornase alfa) [package insert]. South San Francisco, CA: Genentech, Inc; 2021.

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    Non-US Residents visit: Pulmozyme.global